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pentobarbital will lessen the extent or effect of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will increase the amount or effect of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of ivosidenib with robust CYP3A4 inducers reduced ivosi